What Is The Difference Between NAD, NADh, And NAD+?

Nicotinamide adenine dinucleotide, or NAD, is a necessary cofactor and enzyme that cooperates with essential biochemical processes within our bodies. Many medical experts have concluded the functions of NAD are related to those of the aging process and that a downturn in NAD levels may be a contributing factor as to how our bodies decline with age. Apart from NAD’s distinguishable effects, what develops on a fundamental basis and what is the difference between NAD, NAD+, and NADH?

But first, let’s talk about oxidation and reduction

Energy is developed in the body through transferring neurons. Differing molecules are manufactured when electrons change ownership which is a process known as oxidation and reduction. These processes are akin to an exchange of batteries. While one molecule may be in possession of a battery that another molecule lacks, they still require an agent or intermediary to allow them to trade these batteries. It’s instances such as these when cofactors like NAD lends a helping hand.

The roles of oxidation and reduction aren’t solely limited to generating power, however. These processes help to neutralize free radicals (charged molecules which damage the cell) or regulate metabolic and cellular signaling passageways.

Now that we’ve established a clear impression of oxidation and reduction, we can take a closer look at the role NAD has to play in these processes.


NAD therapy restores the NAD inventory within your body, reversing the aging process, equipping cells with the crucial materials needed in order to perform with youthful enthusiasm and vigor. The subsequent and numerous benefits of NAD therapy can include heightened energy levels, improvements in temperament as well as increased mental focus and memory.

NAD is a commonly used name used when describing the various types of nicotinamide adenine dinucleotide and is often an encompassing name used when discussing NAD, NAD+ and NADH. Nonetheless, many scientific writings stringently use NAD+ or NADH due to the fact those terms specify the exact molecule in question. NAD+ is actually just NAD once it’s become oxidized and is widely considered the harbinger of chemical reactions related to NAD.

What happens when a molecule becomes Oxidized?

A molecule possesses a chemical structure capable of obtaining electrons from other molecules. Accordingly, NAD+ contains a chemical structure that can accept electrons from another molecule which activates a multitude of reactions throughout the biological processes.

NAD+ is administered as part of the process of NAD IV therapy, and cells are immediately able to utilize this form of NAD as soon as it is introduced into the bloodstream. Basically, NAD+ is the biologically functional form of NAD containing catalytic properties. The state of NAD is modified after it receives electrons which sees it transform into a diminished form of NAD referred to as NADH.

NADH is the medical title for nicotinamide adenine dinucleotide (NAD) + hydrogen (H). NADH is literally an NAD molecule that has welcomed hydrogen atoms and converted to a condensed state of NAD.

The role of reduction, explained

A chemical structure that has approved additional electrons from another molecule is referred to as a reduced molecule. Accordingly, NADH has a chemical structure that utilizes its electrons to receive two hydrogen atoms, which completes the catalytic oxidation-reduction mechanism of NAD.

The NAD+ NADH cycle

When NAD is introduced to our organs and cells, it acquires electrons and hydrogen atoms from NADH (keep in mind the bonus electrons it has to provide) and converts into NAD+. Concurrently, the NADH contributing electrons develop into NAD+ and the sequence begins again.

NADH and NAD+ are essentially divergent models of NAD, one that contains bonus electrons and one that does not, with electrons exchanged between the two as a catalytic chemical reaction. This reaction goes a long way towards illustrating why decreasing NAD+ levels often lead to a complete breakdown within this chemical reaction.

Furthermore, restoring levels of NAD+ by means of an IV infusion can aid in recovering these reactions optimal levels. Maintaining and preserving peak levels of NAD+ within our bodies should be treated as a top priority.

Oral vs IV NAD

NAD is available through IV therapy or a multitude of supplements available online or in most pharmacies and finding the right way to keep your balance just right may feel a bit daunting. While both oral supplements and IV therapy can raise NAD+ levels, they are not equivalent. Here are a few things to keep in mind when finding what suits your needs.

Oral NAD supplements look adequate on the surface, but a closer look displays an incomplete effect once ingested. This is because the NAD needs to traverse through the gut before entering the bloodstream and the cells in need of it. A significant amount of NAD is lost as a result of issues such as gut absorption and cardiovascular fitness.

On the contrary, an NAD IV infusion is able to circumvent these obstacles by introducing NAD directly to the bloodstream and your cells with complete absorption.

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