hand with a surgical glove holding an injection

PT 141 Peptide Pros and Cons: Understanding Its Benefits And Risks

PT 141 (also called bremelanotide) is a synthetic peptide hormone that can be used to treat sexual dysfunction in both men and women. Unlike treatments that affect the vascular system, PT 141 affects the nervous system, so it not only increases blood flow to the penis or vagina and clitoris, but it also helps increase sexual desire.

However, it is important to understand the benefits and risks associated with PT 141 before pursuing treatment. Continue reading to learn more about PT 141, including the pros, cons, and risks associated with this peptide.

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Pros of PT 141

PT 141 works by stimulating melanocortin receptors in the brain. It can be injected under the skin or inhaled through the nose as a treatment for sexual dysfunction. It is known for taking effect quickly, usually in less than one hour. There are many benefits that this peptide has to offer for men and women struggling with decreased sexual desire and ability.

Treating erectile dysfunction

Erectile dysfunction (ED) can be caused by many factors, including medical conditions, mental illness, or certain medications. There are many types of treatment for ED, but some can cause serious side effects.

PT 141 causes your brain to release nitric oxide, which relaxes the muscles of the penis and increases blood flow to the region.

sad man sitting on a couch

This increase in blood flow can help men with ED achieve an erection.

Increased sexual desire

One thing that makes PT 141 stand out is that it can be used for both men and women. It has been found to improve sexual desire in premenopausal women diagnosed with sexual arousal disorder.

woman looking seductively at the camera

Other benefits of PT 141

Because it also leads to increased desire rather than just increased blood flow to the sex organs, PT 141 also leads to improved sexual performance and has the potential for improved mood and general well-being. This is because people perform better sexually when there is increased desire rather than just increased blood flow alone, as with other types of medications.

Cons of PT 141

Like any other medication, PT 141 can cause side effects. The most commonly reported side effects are:

  • Flushing
  • Headaches
  • Nausea
  • Skin irritation


Flushing is characterized by redness or a feeling of warmth or tingling in the skin. It occurs when the blood vessels in your skin become dilated. Mild to moderate flushing is common with PT 141 use but can be more severe for some people.


PT 141 can also cause head pain and pressure, but this side effect is usually mild to moderate in severity and should go away on its own after a few hours.


Although uncomfortable, queasiness is another common mild to moderate side effect that should resolve itself over time.

woman having a headache and holding her head

Skin irritation

It is likely that you may experience mild to moderate itching, redness, or pain at the injection site after taking PT 141. Like other common side effects, any skin irritation should go away on its own.

Less common side effects

The severity and duration of side effects can vary by individual. Contact your doctor immediately if you experience any of the following serious side effects of PT 141:

  • Blurred vision
  • Darkening of the face
  • Darkening of the gums
  • Dizziness
  • Fatigue
  • Joint pain
  • Joint swelling
  • Runny nose
  • Stuffy nose
  • Vomiting

Other issues

Taking PT 141 can also increase your risk for blood pressure spikes, potentially impacting other medical conditions, such as heart disease.

Risks of PT 141

Although PT 141 shows promise in effectively treating sexual dysfunction in men and women, more research is needed to better understand its long-term effects. There are both known and unknown risks associated with PT 141.

Unknown long-term effects

The long-term effects of PT 141 have not yet been widely studied. This means that experts are uncertain about the safety of taking PT 141 over an extended period, especially for individuals with other health conditions. It is also unknown if PT 141 becomes less effective over long periods.

Black doctor looking at a tablet while he is wearing his glasses and a stethoscope over his neck.

A 52-week study monitored PT 141 use in premenopausal women with hypoactive sexual desire disorder and found that the treatment remained effective for the duration of the study.1

Potential for abuse or misuse

The potential for the abuse or misuse of a drug increases if its effectiveness decreases over time. With most drugs, the body develops a tolerance over time, so a higher dose is needed to achieve the same results. This can lead patients to take more medication than prescribed, which can be dangerous.

yellow pills on a blue background

Possible impact on hormone levels and fertility

More research is needed on the effects of PT 141 on hormone levels and fertility.


PT 141 is a synthetic peptide that stimulates the brain’s melanocortin receptors and causes the brain to release nitric oxide. It can be used to treat sexual desire disorder in women and erectile dysfunction in men by increasing sexual desire and blood flow to the sex organs. It can also help improve sexual performance and elevate mood.

Pros of PT 141 include:

  • Increased sexual desire
  • Increased sexual arousal
  • Improved sexual function
  • Improved sexual performance
  • May lead to improved mood
  • May lead to better overall well-being

Cons of PT 141 include:

  • Potential mild to moderate side effects
    Possible impact on certain medical conditions such as heart disease
    Increased risks for spikes in blood pressure

Due to the cons and risks outlined above, along with the lack of long-term safety data about PT 141, it is important that you discuss PT 141 with your doctor before deciding to take it. This is especially important if you have other health conditions like heart disease or high blood pressure. Your doctor will be able to assess the risks and benefits of taking PT 141, and you can work together to determine whether it may be right for you.

Contact a healthcare provider immediately if you notice any of the less common side effects of PT 141 listed in this article or if a common side effect does not resolve in a timely manner on its own.

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[1] Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder. Simon JA.

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