A woman holding her tummy in pain while having inflammatory bowel disease.

Can Peptides Help With Inflammatory Bowel Disease?

Inflammatory bowel disease (IBD) affects about 3 million adults in the United States. This digestive disease encompasses chronic digestive issues such as diarrhea, abdominal pain, rectal bleeding, and fatigue. Two different conditions can classify IBD: Crohn’s Disease and Ulcerative Colitis.

Peptide therapy is a new, compelling approach to reducing inflammation in the body that may be helpful with inflammatory conditions like IBD. This article provides insight into peptides and how they can treat inflammatory bowel disease.

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What is IBD?

Inflammatory bowel disease is a common disease that affects the digestive tract. There are two main types of IBD, and symptoms can vary from person to person. Keep reading to find out more.

Types of IBD

The two common types of IBD are Crohn’s disease and ulcerative colitis.

  • Crohn’s disease is characterized by an inflammation of the digestive tract lining, typically involving the deeper layers of the digestive tract. Crohn’s disease can affect the large and small intestines but more commonly affects the small intestine. In rare cases, it can affect the upper GI tract as well.
  • Ulcerative colitis causes sores in the lining of the large intestine and rectum.

IBD Symptoms

A woman experiencing IBD symptoms curled up and holding her stomach in pain while laying on her couch.Inflammatory bowel disease symptoms vary based on the severity of the inflammation and the affected part of the digestive tract. Patients can experience mild or severe symptoms. The disease can often spontaneously occur before remission, only to become active once again.

Common symptoms of IBD include:

  • Diarrhea
  • Cramping and abdominal pain
  • Bloody stool or rectal bleeding
  • Poor appetite
  • Unexplained weight loss
  • Fatigue.

What are Peptides?

A top view of 8 eggs in a carton box while one of them is cracked and half opened. You can see the yellow yolk inside. It basically represents peptides as proteins.Peptides are short chains of amino acids that occur naturally in the body and are the building block of proteins. Peptides can be manufactured and sold as supplements. Many people take peptides as a supplement for health benefits. Many different types of peptides serve specific purposes in the body. Some peptides act as a hormone, communicating information to varying tissues through the blood.

Potential benefits of peptides include the following:

  • Anti-aging benefits for the skin
  • Helping the body fight infection and heal
  • Boosting muscle growth and repair
  • Helping with weight loss.

Due to their significant beneficial properties (antioxidants, antimicrobial, and antithrombotic), peptides have emerged as effective medical treatments. The peptides contained in medicine may be naturally occurring or synthetic.

Some examples of peptides designed for medicinal use include:

  • Vasopressin1 is a peptide that can manage diabetes and help with antidiuretic hormone deficiencies.
  • Carnosine is a type of dipeptide that might be useful in treating conditions like Alzheimer’s disease, autism, down syndrome, and Parkinson’s disease.
  • Chromofungin2 is a peptide that might help treat inflammatory bowel disease.

How Peptides can Help with Inflammatory Bowel Disease

Peptides have become a promising new treatment for inflammatory bowel disease. Multiple studies have looked at the effects of peptides on IBD. [1][2][3][4] Research is ongoing to determine the safety of treating IBD with peptides in humans, but the studies have shown promising results in reducing inflammation.

Reducing Inflammation

One study found that peptides could mimic good cholesterol, which helped to treat the underlying inflammation associated with IBD in mice. The results of this study prompt further research using similar methods in humans.

Another study3 reviewed the current literature to point to using peptides as a treatment for IBD. This study concluded that vedolizumab is one of the most promising peptides against IBD.

Causes of Inflammatory Bowel Disease 

A woman smoking and exhaling smoke while her other side of the face is reflected in a oval mirror.The cause of IBD is unknown. Diet and stress may exacerbate this condition but are not necessarily the cause of IBD. Immune system malfunction may be a potential cause of IBD. Gene mutations can also contribute to IBD, meaning you are more likely to develop IBD if someone in your family has it.

Other risk factors of IBD include:

  • Age: the average age of diagnosis for IBD is 30 years old, but many cases have occurred later in life.
  • Smoking: Cigarettes can increase the risk of developing Crohn’s disease and its severity if you already have it.
  • Taking NSAIDs: NSAIDs or Nonsteroidal anti-inflammatory drugs, such as ibuprofen and naproxen sodium, can increase the risk of getting diagnosed with IBD.

IBD Treatment 

There is no definitive cure for IBD, but medications and surgeries are available to treat and manage this disease. Medications to help relieve painful symptoms and prevent them from worsening are prevalent. However, in many cases, drugs are ineffective, and surgery is required to remove the affected section of the digestive tract.

Revitalize with Peptide Therapy

Peptides are short chains of amino acids that serve as building blocks for proteins and play crucial roles in many biological functions. Combat age-related decline of peptides in your body with our scientifically formulated peptides, which offer a range of health benefits:

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[1] Bankir L, Bardoux P, Ahloulay M. Vasopressin and diabetes mellitus. Nephron. 2001 Jan;87(1):8-18. doi: 10.1159/000045879

[2] Eissa N, Hussein H, Kermarrec L, et al. Chromofungin Ameliorates the Progression of Colitis by Regulating Alternatively Activated Macrophages. Front Immunol. 2017 Sep 15;8:1131. doi: 10.3389/fimmu.2017.01131

[3] Herrlinger KR, Stange EF, Fellermann K. Therapeutic peptides in inflammatory bowel disease. Expert Opin Biol Ther. 2014 Apr;14(4):455-66. doi: 10.1517/14712598.2014.880109

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