scientist in a lab

Lab Tests That Can Detect Problems With Growth Hormone Production

Synthesis and regulation of growth hormone (GH) are crucial for maintaining health due to its significant impact on human metabolism and growth.1 The IGF-1 subtest of the Comprehensive Wellness Panel is essential for diagnosing issues related to growth hormone production.2 Physicians can assess growth hormone function and identify conditions such as acromegaly or growth deficiencies by examining IGF-1 levels, which are more consistent than GH levels. Monitoring IGF-1 levels is crucial in endocrinology for diagnosing and treating conditions, as it allows for evaluating the effectiveness of growth hormone therapy.

Order A Lab Test Now with Concierge MD!

Take control of your health from the comfort of your home! Discover personalized insights with our at-home lab tests – order now for convenient, confidential results that empower your well-being.

Growth hormone (GH) is a vital component in human metabolism and growth, influencing several aspects such as energy levels and physical development. Identifying concerns with growth hormone production is crucial for diagnosing and treating many health conditions, including hormonal imbalances in adults and growth abnormalities in children. Laboratory testing is crucial in revealing the intricate functioning of the endocrine system.

scientist in a lab

These tests can help clinicians pinpoint abnormalities in growth hormone synthesis by accurately measuring specific hormones and related markers, which can facilitate timely and effective treatment strategies.

Comprehensive Wellness Panel

The IGF-1 subtest of a Comprehensive Wellness Panel can detect issues related to growth hormone production.3 Growth hormone and IGF-1 are closely associated hormones commonly utilized as indicators to assess growth hormone function in the body. Abnormalities in IGF-1 levels might indicate issues with the manufacturing of growth hormone.
The pituitary gland releases growth hormone (GH) to increase the creation of insulin-like growth factor 1 (IGF-1), mostly generated in the liver. There is a significant link between blood levels of growth hormone and IGF-1.

Problems with growth hormone production are diagnosed utilizing IGF-1.

Growth hormone levels fluctuate daily due to its production in pulses.4 IGF-1 levels are more stable and reliable than growth hormone levels over time.

IGF-1 is involved in regulating the production of growth hormones through a feedback loop.5 Elevated IGF-1 levels prompt the pituitary gland to reduce the production of growth hormone, whereas low levels stimulate increased synthesis. Doctors can assess the degree of growth hormone activity by measuring IGF-1.

Assessing IGF-1 levels can help verify the diagnosis in cases when a patient shows symptoms of growth hormone excess (acromegaly in adults) or deficiency (stunted growth in children). Low IGF-1 levels may indicate a deficiency in growth hormone, whereas high levels may signal an excess of growth hormone.

IGF-1 levels are monitored in patients receiving growth hormone therapy to assess the effectiveness of treatment and adjust dosage if needed.

The intermittent secretion of growth hormone complicates the direct measurement of its levels. IGF-1 provides a more dependable and indirect measure of growth hormone function throughout time.

Final Thoughts

Testing for growth hormone production includes many laboratory methods such IGF-1, GH stimulation and suppression tests, and further assessments of related hormones. These tests provide clinicians with valuable information about the complex relationships between hormones in the body, aiding in the diagnosis and effective treatment of conditions related to growth hormone irregularities. Advancements in endocrinology are enhancing the precision and value of these tests, offering patients with growth hormone-related conditions optimism for improved outcomes.

Get your at Home Lab Test with Concierge MD

If you need a lab test but want to avoid traveling to the doctor’s office, consider Concierge MD as an option. We are a licensed mobile healthcare provider with a wide range of services, including lab testing. You can make an appointment online or over the phone for one of our healthcare specialists to visit you in your home and collect samples for one of our many accessible lab tests:

  • Wellness Panel
  • Male Hormone
  • Female Hormone
  • STD Panel
  • Thyroid Panel
  • Anemia Panel
  • Food Sensitivity
  • Genetic Cancer Screening
  • Micronutrient
  • Gut Microbiome
  • Inflammation Panel
  • Heavy Metal Panel
  • Sleep and Stress Panel
  • Urinary Health Panel
  • Vaginal Health Panel
  • and more… 

Our staff will assure the safe delivery of samples to our lab. When your results are ready, we can assist you in interpreting them and help you move forward toward a better self. Concierge MD is a private and professional healthcare service that focuses on you. Contact us immediately to order your lab testing!


[1] Vijayakumar A, Yakar S, Leroith D. The intricate role of growth hormone in metabolism. Front Endocrinol (Lausanne). 2011 Sep 27;2:32. doi: 10.3389/fendo.2011.00032. PMID: 22654802; PMCID: PMC3356038.

[2] Al-Samerria S, Radovick S. The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth. Cells. 2021 Oct 5;10(10):2664. doi: 10.3390/cells10102664. PMID: 34685644; PMCID: PMC8534318.

[3] Laron Z. Insulin-like growth factor 1 (IGF-1): a growth hormone. Mol Pathol. 2001 Oct;54(5):311-6. doi: 10.1136/mp.54.5.311. PMID: 11577173; PMCID: PMC1187088.

[4] Hartman ML, Veldhuis JD, Thorner MO. Normal control of growth hormone secretion. Horm Res. 1993;40(1-3):37-47. doi: 10.1159/000183766. PMID: 8300049.

[5] Romero CJ, Pine-Twaddell E, Sima DI, Miller RS, He L, Wondisford F, Radovick S. Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions. Mol Cell Biol. 2012 Nov;32(21):4258-69. doi: 10.1128/MCB.00171-12. Epub 2012 Aug 13. PMID: 22890843; PMCID: PMC3486141.

Experience Care with ConciergeMD

ConciergeMD offers coverage throughout the United States.