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Enclomiphene Vs. TRT: Which Is Right For You?

Testosterone is an important part of the male body for a number of reasons. Throughout their lives, men go through varying levels of testosterone in their bodies. Although some fluctuation is normal, some men seek out treatment to raise and maintain testosterone levels. In this article, you’ll get a brief look at how enclomiphene and TRT differ and which one might be right for you.

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Understanding Enclomiphene

With a primary aim of increasing testosterone levels, enclomiphene helps to maintain sperm levels, specifically in men with hypogonadism.

The drug can be utilized in both capsule and liquid forms, and it’s classified as a non-steroidal estrogen receptor antagonist.

Enclomiphene is also known to have applications for treating prostate and breast cancer. The efficacy of enclomiphene is comparable to topical testosterone treatments.1 Aside from testosterone, it’s known that enclomiphene can increase LH and FSH levels in the body. One of the biggest draws about enclomiphene is that it allows men to remain fertile throughout their treatment.

4 syringes on a blue background

Dosage and Side Effects

Enclomiphene is generally available in either 12.5 mg or 25 mg doses. Both may help men dealing with low testosterone. Although the drug and its effects are straightforward, it comes with its own set of potential side effects that men should be aware of.

Some side effects of enclomiphene include:

  • Acne
  • Increased libido levels
  • Complications with temper management
  • Headaches
  • Nausea

Potential side effects are bound to vary from one patient to the next, and their presence is not guaranteed by any means. However, they shouldn’t be taken lightly either, as they can exacerbate health concerns, causing more issues than just low levels of testosterone.

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Testosterone Replacement Therapy (TRT)

Men who are dealing with low counts of testosterone can benefit from testosterone replacement therapy (TRT). Whether due to a medical condition or normal aging, many men encounter lower T-counts at some point in their lives.

TRT has been shown to have some positive effects on men’s health outside of testosterone. Many have seen improvements in their sexual performance, building muscle mass, and boosting everyday energy levels. Another appealing aspect about TRT is the multiple options for administration.

Popular methods include:

  • Topical creams
  • Oral administration
  • Intramuscular injections
  • Transdermal patches

Although the results TRT provides have ended up in many satisfied patients, there are a few risks that should be considered beforehand.2 While research on TRT will always be ongoing, experts have a pretty concrete list of potential health risks associated with the treatment. Aside from navigating the side effects, proper dosage is equally important in regard to safe administration.

Dosage and Side Effects

There are still many conflicting bits of information on the full scope of health risks related to TRT. With many factors affecting how a patient responds to TRT, experts continue to explore the potential implications of the treatment. Nevertheless, there are several potential TRT side effects, including but not limited to:

  • Difficulty breathing
  • Cardiovascular issues
  • Sleep apnea
  • Acne
  • Deep vein thrombosis
  • Low sperm count

Keep in mind that these aren’t a guarantee, but it is important to take note of them before diving into the treatment. If you already have any of the issues mentioned above, there’s a good chance your doctor may recommend that you avoid TRT and explore other treatment options.

A Comparative Analysis of Medical Applications

When you compare enclomiphene and TRT at a glance, they seem to essentially serve the same purpose. However, there are some differences between them that might sway a patient’s decision on which treatment they would like to pursue.

From a medical standpoint, TRT is generally chosen to focus on patients with primary and secondary hypogonadism. TRT can be applied to help balance varying T levels that stem from a list of different causes. It’s also known that the treatment has multiple non-medical applications in regard to weight loss, boosting sex drive, increasing energy levels, and more.

With enclomiphene, you get many of the same benefits as TRT while still being able to maintain sperm count in the process of your treatment.

older man lifting weights

Enclomiphene also acts to naturally stimulate the body’s production of testosterone and is gentler on the body with fewer severe side effects.

TRT is FDA approved while enclomiphene currently is not, and there is more research available on TRT compared to enclomiphene.

Which is Right For You?

For each patient, it generally comes down to a blend of their current health condition, personal preferences, and doctor recommendations. As research expands in the coming years, new developments could sway opinions about enclomiphene and TRT. In the meantime, both will continue to serve their target markets, and men will continue to benefit from what these medications have to offer.

Last Words

Working closely with medical professionals on the topic is the best way to stay on top of your health. Managing testosterone levels can come with a long journey, and you want a treatment that’ll keep you healthy along the way.

At Concierge MD, we take pride in offering personal, at-home medical care to those who need it most. We provide a wide range of medical services, and when it comes to the administration of testosterone treatments, we’re more than happy to support you on this journey in the comfort of your home.

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[1] Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men. Hill S.

[2] Risks of testosterone replacement therapy in men. Osterberg EC.

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